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Metabolomics and lipidomics datasets supporting the findings of this study are provided in Supplementary Table 12

The CDC maintains a weekly updated US Influenza Surveillance Report website that provides information on current trends for the incidence of influenza viral infections, and the susceptibility of different viral strains to antiviral medications ( As an example, for the week of Sept 28, 2025, the resistance of all viral strains to oseltamivir (3.953 viruses tested) was 0.04% with reduced inhibition, and 0.02% with highly reduced inhibition ( Although oseltamivir resistance remains uncommon at present, its unpredictable emergence under selective pressure has reinforced the importance of maintaining multiple antiviral options, including other neuraminidase inhibitors (zanamivir, peramivir, laninamivir) and agents with distinct mechanisms such as baloxavir marboxil (Lampejo, 2020

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