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Regarding liver and kidney damage in MTX treatment, Bedoui stated that MTX hepatotoxicity may occur due to the depletion of folate reserves and MTX-polyglutamate formation in the liver (Reference Bedoui, Guillot and Slambarom41)

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Anyone with a G6PD deficiency: Glucose-6-phosphate dehydrogenase deficiency is a genetic condition that makes people prone to hemolytic anemia under oxidative stress

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Free Radic Biol Med 78:4255

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Autophagy is extensively involved in various cellular processes associated with physiological and pathological conditions 12

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