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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Nevertheless, the efficacy of these interventions necessitates validation through multicenter randomized controlled clinical trials

Therefore, understanding whether IF can mitigate these factors by improving both inflammatory and oxidative stress markers, as well as liver enzyme profiles, could offer a novel, non-pharmacological strategy for managing RA and its associated metabolic complications in this vulnerable population