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Torres-Cabala CA , Li Ning EML, Palau MA, Zbar B, Linehan WM, Merino MJ

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Observed biological activities in research: Activation of IGF-1 receptor signaling Increased cellular protein synthesis Enhanced glucose uptake in experimental models Promotion of cell proliferation and differentiation Support of tissue remodeling and regeneration pathways Molecular mechanisms reported: IGF-1 receptor activation PI3K/AKT pathway stimulation MAPK/ERK signaling activation Regulation of mTOR-associated anabolic signaling Modulation of gene expression involved in cell-cycle progression Physiological pathways involved: IGF-1 signaling axis Cellular metabolism Skeletal muscle regeneration Connective tissue remodeling Neurotrophic signaling Cardiovascular cellular physiology Experimental outcomes in models: Increased muscle satellite cell activity Enhanced tissue repair responses Improved neuronal survival in laboratory models Altered glucose utilization and metabolic signaling Increased anabolic cellular responses Current evidence remains limited, and further well-controlled clinical studies are required to establish long-term efficacy and safety in humans