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Shadab and colleagues achieved nanoencapsulation of betamethasone valerate into chitosan-based nanoparticles (BMV-CS-NPs) for enhanced dermal targeting and improved skin permeation

Methyl-THF cannot be converted back to methylene-THF because this reaction is not reversible (Figure 3)

10.1021/bc800448u 236 StrebhardtK.UllrichA