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Similarly, NAC has been shown to alleviate moderate depressive symptoms (Liang et al., 2022) by curbing ROS production in microglia (Lehmann et al., 2019) and regulating the glutamatergic system in the PFC (Nery et al., 2022)

Disclosure of interest: MA has received consultancy fees from Janssen Pharmaceuticals and Janssen Scientific Affairs for being on the Steering Committee of the Quantum AF study