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Astrocytic energy metabolism and glutamate formation relevance for 13 C-NMR spectroscopy and importance of cytosolic/mitochondrial trafficking

5.4 Mitochondrial dysfunction as an upstream driver of amyloid and tau pathology A significant shift in Alzheimer's disease (AD) research is represented by the Mitochondrial Cascade Hypothesis, which posits that mitochondrial dysfunction is the primary driver of AD pathophysiology, rather than a secondary consequence of Tau or A accumulation (94)

Acknowledgements The authors are thankful to Integral University, Lucknow, and Eras Lucknow Medical College and Hospital, Era University, Lucknow for providing their assistance during this work

doi: 10.1186/s12905-023-02515-9