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Human-equivalent-dose extrapolation from that protocol lands around 650 mg/day for an 80 kg adult, but no human has been studied at any dose in a published trial

NAD+ precursors repair mitochondrial function in diabetes and prevent experimental diabetic neuropathy

However, according to the National Institute of Child Health and Human Development, folic acid supplementation reduces the risk of neural tube defects in all pregnant women, including women with an MTHFR variant

Symptoms of Vitamin B12 Deficiency Vitamin B12 deficiency results in symptoms common to a variety of disorders, so blood work and other diagnostic testing may be necessary to rule out other problems