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Biological metals and metal-targeting compounds in major neurodegenerative diseases

This facilitates autophagy-dependent ferroptosis, further amplifying lipid peroxidation under stress conditions

After removal of volatiles under reduced pressure, the reaction mixture was purified by chromatography on silica gel (DCM/MeOH gradient from 99:1 to 95:5) to afford 42 mg (62%) of compound INT3 as a yellow/greenish solid

The Foundation FAPESP did not influence in the design of the study and collection, analysis, and interpretation of data or the writing of the manuscript