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However, in marked contrast to previous in vivo studies 33,34 , CB-839 administration to KP and KPH2 animals substantially inhibited tumour growth, as calculated from the difference in the muscular compartment of tumour-bearing limbs (red) relative to control limbs (green) (Fig

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[1] The GSH/GSSG redox couple, glutathione peroxidase, glutathione-S-transferase, and the gamma-glutamyl cycle are well-characterized and central to cellular defense and detoxification