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The maturation of selenocysteine-tRNA can be regulated by the pentadienoic acid (MVA) pathway, which in turn can impact the synthesis of GPX4 and the development of ferroptosis (52)

Virgin media controls were generated by incubating the treatment media in cell-free 6-well plates under the same conditions and duration as the cell culture samples

*Correspondence: Lieven Lagae [email protected] This article was submitted to Epilepsy, a section of the journal Frontiers in Neurology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers