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These trials did not show clear advantages over placebo on standard PD scales, partly because sample sizes were small and placebo groups improved

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Comparison to a contemporaneous cohort of conventional DLI therapy suggested improved response rates with Treg depletion ( 3.4.4 - Alloanergization Alloanergization is an approach to prevent GVHD by tolerizing alloreactive donor T cells to the recipient through chronic antigen stimulation with concurrent co-stimulatory blockade, thus leading to T cell anergy and hyporesponsiveness to alloantigens (155)

doi: 10.1016/j.siny.2017.07.003 18 CummingsJJPramanikAK