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These phosphorylated R-SMADs dissociate from the receptor and form a trimeric complex with SMAD4, which translocates into the nucleus to regulate transcription of fibrosis-related genes, including -smooth muscle actin (-SMA) and collagen I [40, 41]

Occasional, moderate drinking is usually safe for most people

Other studies have also found mixed results with no significant differences in periodontal variables between COPD and non-COPD groups, except for probing depth that was greater in the non-COPD group [47]

From blood to the brain: can systemically transplanted mesenchymal stem cells cross the bloodbrain barrier