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While dietary contributions typically account for 10%20% of total body CoQ10, this proportion increases in individuals with impaired biosynthesis, such as those with genetic mutations in COQ genes ( Lactobacillus , have been identified to synthesize CoQ homologs, which may be absorbed in the colon and subsequently converted into CoQ10 within host tissues ( A study investigated the relationship between CoQ10 and female fertility and indicated that CoQ10 can support healthy oocyte development in women, prevent premature ovarian failure, and increase ovarian sensitivity to estrogen, ultimately leading to improved ovarian function ( in vitro fertilization and embryo transfer (IVF-ET) treatment, resulting in a higher success rate of embryo transfer (Zhang et al., 2020)