intracellular glutathione pool Glutathione-Related Enzymes and Proteins: A Review Mitochondrial Glutathione in Cellular Redox

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[Google Scholar] 63.Seo H., Oh H., Park H., Park M., Jang Y., Lee M

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Notably, active mTORC1-S6K1 signaling forms a negative feedback loop in the GF signaling pathway, through an S6K1-dependent inhibitory phosphorylation event on IRS-1 (insulin receptor substrate 1), which is important for fine-tuning the cellular response to GF and in the development of resistance to mTOR inhibitors (Harrington et al., 2004