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Johns wort, SAMe (S-adenosylmethionine), valerian DRUGS IN THIS FAMILY: Citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), vilazodone (Viibryd), vortioxetine (Trintellix) 5-hydroxytryptophan (5-HTP) Effect: Possible Harmful Interaction The body uses the natural substance 5-HTP to manufacture serotonin, and supplemental forms have been used for treating depression and migraines