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In rodent satellite-cell models, sustained IGF-1R activation by long-acting analogues increased myotube diameter by 30-40% compared with vehicle, an effect attenuated by the PI3K inhibitor LY294002 [5]

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Most of these studies have suggested clinically relevant reductions in migraine frequency and severity, but are limited by lack of placebo control (four out of seven studies)

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doi: 10.1128/AEM.68.9.4672-4675.2002, 214 ShahidM.KhanM

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The final cost may change if the infection is deeper than expected, if intravenous antibiotics are required, if an abscess needs drainage, if additional tests are needed, or if underlying conditions require closer monitoring.

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