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Neuroscience & Biobehavioral Reviews, 26(1), 31-44

All documented evaluations are confined to investigational, analytical, and preclinical research models, with no application beyond laboratory-based examination

Nevertheless, the discovery of an extra-hepatic IGF-I production in the following years[18, 45], made it necessary to spand the conception of the GH/IGF-I axis, being well accepted nowadays that pituitary GH is able to induce IGF-I synthesis in both liver (~75%) and other tissues[23, 46, 47], which subsequently, is able to act in an endocrine/paracrine/autocrine manner