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(The term P450 refers to the 450-nm absorption peak characteristic of these heme proteins when they bind carbon monoxide.) The net result of a cytochrome P450-dependent oxidation reaction is: The reaction proceeds when the drug binds to the oxidized (Fe 3+ ) cytochrome P450 to form a complex, which is then reduced in two sequential oxidation/reduction steps as outlined in Figure 4-2A

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While our objective was to determine the rates of hepatotoxicity for the 2 routes, the optimal meta-analysis would compare oral and IV administration