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To increase the entropy of water following exposure of HNE-bound hydrophobic regions of the proteins (14), other exposed hydrophobic regions of the same or different proteins will interact, i.e., this leads to protein aggregation of similar or different HNE-bound proteins (15)

Mycotoxins have been reported to alter the antioxidant systems, including glutathione transferase (GST), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and glutathione reductase (GR)

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However, hormonal involvement has also been identified as contributing to changes across different neurotransmitter systems (118, 119)