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However, stress, infection, traumatic brain injury (TBI), trauma, and/or neurotoxic exposures (43, 6568), all commonly experienced by GW veterans, can cause permeability of the BBB to occur, which may allow higher quantities of dietary glutamate to cross into the brain

These ferroptosis markers should be interpreted together with established diagnostic tools, including CSF A42, phosphorylated tau, total tau and A PET imaging (97)

For precise assessment, analytical techniques such as HPLC or mass spectrometry may be used

The trial product estimand addressed the average treatment effect in all randomly assigned participants, assuming that the drug or placebo was taken as intended (participants on treatment)