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Hence, the disturbance of the circadian clock leads to a number of cellular misregulations, including the downregulation of immune responses (Grundy et al., Circadian Clock Associated 1 ( CCA1 ) (Lai et al., 2012)

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Clinical trials and meta-analyses indicated that concurrent administration of GnRH agonists during chemotherapy markedly reduced the incidence of POF and enhanced the likelihood of restarting menstruation and ovarian function following treatment (Blumenfeld and Wolff 2008