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There is a positive feedback relationship between p62 and the Nrf2 signaling pathway, with phosphorylated p62 preempting Keap1 through the KIR region, thereby releasing Nrf2 into the nucleus to initiate p62 expression (Silva-Islas and Maldonado, 2018)

This study does not include humans

Factoren die de expressie en/of activiteit van MnSOD benvloeden zorgen voor een verminderde antioxidantcapaciteit van de cel, wat buitengewone gevolgen voor de algehele gezondheid van de cel kan hebben door een verandering in de mitochondriale metabolische functie (Holley, et al., 2011)

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