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Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methyl malonyl coenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate-limiting step in the synthesis of methionine

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Variants at the HMIP-BCL11A-HBB loci account for 2050% of the variability of HbF levels and the relative contributions of these variants differ between ethnic groups [19], [20], [21], [22], [23]