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As is the case with phenobarbitone-like enzyme induction, peroxisome proliferating compounds are associated with liver tumors in rats and mice following prolonged exposure (Greaves 2007

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Crucially, there is a marked increase in telomere attrition rates with each cell division cycle under these conditions

doi:10.1371/journal.pone.0040365 Philippova M, Joshi MB, Pfaff D, Kyriakakis E, Maslova K, Erne P, Resink TJ (2012) T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells