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Rescue experiments reveal that vitamin E is essential for preventing necroptotic cell death and suppressing anemia caused by GPX4 deletion [10]

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Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase

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For instance, beyond their DHAR activity, fungal and bacterial GHRs characterized so far efficiently reduce glutathionylated (chlorinated) (hydro)quinones with k cat around 10 3 s 1 and k cat / K m up to 10 6 M 1 .s 1 (Table 5) (Huang et al., 2008