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In animal models, oral administration of crocodilian oil revealed no signs of acute toxicity, indicating its safety as a dietary supplement (16)

The IV administration is performed by seating the patient, placing a tourniquet on their upper arm, and disinfecting the entry point

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Synthesis, biological evaluation and molecular modeling study of 2-(1, 3, 4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors