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The expression of MMP-9 in subcutaneous adipose tissue, a marker of ECM degradation, is higher in metabolically unhealthy obese individuals compared to metabolically healthy lean individuals (127), suggesting that obesity is more prominently associated with ECM degradation in adipose tissue

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Randomized trial of preladenant, given as monotherapy, in patients with early Parkinson disease

Furthermore, iron serves an essential role in brain development and function, and is involved in various biological processes, such as embryonic neuronal development, myelination, neurotransmitter synthesis and oxidative phosphorylation (19)