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Interestingly, Chen and coworkers demonstrated, in chronic unpredictable mild stress protocol, the beneficial effects of chaingun granules, which lead to neuroprotection through the reduction of xanthines content and ROS, antidepressant effects observed in SPT, FST, OFT and EPM and anti-inflammatory response by inhibiting the xanthineP2X7R-NLRP3 inflammasome pathway and decreasing TNF-alpha, IL-1

Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota

This work further utilizes molecular dynamics (MD) simulations to simulate the delivery of the drug using a SWCNT onto the receptor

All of the experiments were approved by the local ethics committee