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It gets into bone marrow and brain tissue

171,172 Additionally, PTEN loss alters the extracellular matrix (ECM) through the yes-associated protein 1 (YAP1) and lysyl oxidase (LOX) axes, facilitating angiogenesis and macrophage infiltration, which further supports tumor growth

doi: 10.1016/s1043-2760(00)00370-2 92 GuzmanM.BlazquezC

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