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Rinne JO, Portin R, Ruottinen H, Nurmi E, Bergman J, Haaparanta M et al (2000)

Exp Hematol 20(5):569-75, 1992

Cisplatin can strongly bind to mercaptan metabolites produced by GGT-mediated GSH cleavage, reducing Pt ion entry into cells and inactivating Pt drugs outside the cell (136)

These compounds have the effect of alleviating APAP-induced liver injury and can be further developed as antioxidants or hepatoprotective agents (Figure 2)