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Starting from one of the first studies on this topic, it has been demonstrated that missense mutations on codon 132 in IDH1 gene are present in different tumor types diverse than glioblastoma multiforme or gliomas, including prostate carcinomas [43], opening the way to the investigation of the role of 2-HG also in this tumor type

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Summary During treatment, the development of drug-resistant tumours remains an important challenge in cancer treatment

However, factors such as age, poor nutrition, and exposure to toxins can deplete glutathione levels in the body, leading to various health issues