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Once keto-acids are imported into chloroplasts by BAT5, they enter several cycles of reactions including: condensation with acetyl-CoA catalyzed by a MAM, isomerization by an IPMI, and oxidative decarboxylation by an IPMDH ( Figure 2 , transporter 8 and/or transporter with unknown identity)

doi: 10.1016/j.dsx.2019.01.047

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Until the FDA completes the process of creating the full positive list, any items that remain in Category 1 of the interim substance list are still eligible as active ingredients for human compounding