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doi: 10.1186/s10194-016-0688-8

In clinical use, significant side effects are uncommon, and the vast majority of patients tolerate the therapy without problems

Rhoads et al

[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe