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Furthermore, white-matter changes may be state dependent, as one study reported ventromedial prefrontalstriatal, inferior fronto-occipital, and inferior and superior longitudinal fasciculi white-matter alterations in the bipolar depressed state, differentiating it from both remitted patients and healthy controls (135)

Maintenance Phase (6+ months) What to expect: Sustained benefits with continued therapy Stable optimal hormone levels Long-term improvements in vitality and wellness Lab monitoring: Annual comprehensive testing to ensure continued safety and effectiveness