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Positron emission tomography (PET)-based imaging of the high uptake of a radioactive fluorine-labeled glucose analogue 18F-fluorodeoxyglucose (18F-FDG) by cancer cells is used as an imaging tool for the detection of several cancers and for the monitoring of treatment response [4]

the method comprises conjugating the sulfur atom of the thiol to a carbon atom of the carbon-carbon double bond of the first lipid containing conjugation partner and then conjugating a carbon atom from the carbon-carbon double bond to which the thiol is conjugated to a carbon atom of the carbon-carbon double bond of the second lipid-containing conjugation partner

Targeting of lipid particles using a variety of targeting moieties, such as ligands, cell surface receptors, glycoproteins, vitamins (e.g., riboflavin) and monoclonal antibodies, has been previously described (see, e.g., U.S

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