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Although the exact mechanism that drives the development of NASH from simple steatosis is unclear, lipotoxic lipid-inflicted cell injury is proposed to be a major contributor (Neuschwander-Tetri, 2010)

Figure 2 3.4 Antioxidant analysis The antioxidant activity of plant extracts is being assessed to estimate their medicinal value, because antioxidants play a vital role in scavenging free radicals and preventing diseases associated with oxidative stress (47)

SMG1 and SMG7 kinase inhibitors are another class of agents explored for NMD inhibition, as SMG-mediated UPF1 phosphorylation is a crucial step in NMD activation [156, 157]

NNMT-DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition