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In conclusion, constructing separation mutants that specifically alter phase behavior without disrupting protein function, developing genuine condensate modulators capable of modifying transition thresholds and state conversions, identifying LLPS vulnerabilities within RCD, and uncovering key hub molecules across multiple cell death pathwaysthese strategies will not only help elucidate the biophysical principles of phase separation in RCD but also provide highly specific potential therapeutic avenues for intervening in RCD-related diseases

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R.ZhengJ.Wohlford-LenaneC.AbrahanteJ