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3 Thyroidbrain axis pathophysiology and neurological manifestations The major mechanistic routes linking thyroid dysfunction to neuropsychiatric manifestations are summarized in Figure 2, highlighting disrupted hormone transport/activation in the brain, neurotransmitter imbalance, oxidative stressneuroinflammation, and bloodbrain barrier vulnerability

In agriculture, the impact of these simultaneous stress conditions creates crop damage of different magnitudes

Hyperexcitability of individual neurons is another AD-linked phenotype, but we were unable to detect significant changes at the electrode level, again, likely due to the challenges of assigning effects to individual neurons with or without inclusions

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