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Central to this is the ability of the copper ion to transition between the oxidation states Cu(II) and Cu(I)

As the most abundant glial cells in the brain, astrocytes exhibit a dual role in the progression of IS

This paradox may be explained by the antioxidant paradox, where excessive scavenging of ROS disrupts their physiological role in capacitation and acrosome reaction (Dutta et al., 2022)