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Finally, UDP-glucuronate is generated from UDP-glucose by UDP-glucose dehydrogenase, a NRF2-regulated enzyme [70, 71]

Studies from the Butterfield laboratory reported the increased oxidation of several enzymes involved in glucose catabolism, as follows: fructose bisphosphate aldolase (FBA), triose-phosphate isomerase (TPI), phosphoglucomutase 1 (PGM1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), alpha-enolase (Eno1), and pyruvate kinase (PK) (TABLE 4 and FIGURE 10)

Simultaneously, its antibacterial action helps maintain a healthy immune environment, enabling better-coordinated cellular immune responses against both tumors and bacteria, which ultimately contributes to improved patient outcomes and the potential for long-term relapse-free survival

Free Radical Biology and Medicine, 19 (2), 227250