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Acknowledgements This work was supported by the National Natural Science Foundation of China (82073313 to D.L.), the joint project of the State Administration of Traditional Chinese Medicine and Health Commission of Shandong Province (GZY-KJS-SD-2023-094), the Traditional Chinese Medicine Special Project of Binzhou Medical University Affiliated Traditional Chinese Medicine Hospital (2023ZYZX02) and the 2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation Project (to D.L.)

Conclusions As CD38 is overexpressed by many cancer cells, particularly in hematological cancers, it is an important target for treatment

And while human anecdotal and case reports are abundant, human clinical research remains limited, and we would ultimately like to see more well-designed human studies in the near future

Strength training builds muscle under the skin, which can "fill in" some of the space where fat used to be, making loose skin look firmer