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To assess whether the senescent phenotype induced by T-DXd was reversible or sustained, we performed washout experiments at different time points: in particular, cells treated with the ADC were allowed to recover in normal growth medium for either 3 or 7 days after the end of treatment

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Lowered serum concentrations of vitamin B12 are unlikely to be corrected by using 36 g/day B12 from food supplements or high oral B12 (1000 g) provided once weekly [30,73,79]

10.1016/s0006-8993(97)00155-8 158 PierreK.PellerinL