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One of the key questions at this point, as Jerne explained, was whether 'the mouse contains a small number of pre-committed cells that are the only cells that can respond to a given antigen, or the mouse contains a small number of pre-formed antibody molecules of a certain type that have to attach to the antigen as a first step toward antibody formation' (Jerne, 1966)

Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM-Y, et al

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Free urate crystals have considerable pro-inflammatory potential, via the ability to activate synovial lining cells and leukocytes, to induce cleavage of C5 and subsequent activation of the membrane attack complex of complement, and to trigger certain other inflammatory cascades