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Moreover, analyses of immunoglobulins demonstrated a decreased production of IgA, IgG and IgM in smokers [7880] while a study on the avidity of IgG using modified VLP ELISAs revealed that the higher risk of having the low avidity of HPV16/18 IgG in B cells was also associated with cigarette smoking [81]

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Nevertheless, their joint effects are easier to assess reliably because the number doing both is large, as is the twofold mortality RR comparing them with men doing neither