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Initially employed in medical settings during the early 20 th century, O 3 therapy gained prominence for treating gangrene during World War I

Astrocytic low-density lipoprotein receptor-related protein 1 (LRP1) can promote astrocyte-to-neuron mitochondria transfer by inhibiting glycolysis and ARF1-K73la, thereby mitigating cerebral ischemia

In addition, it appears to modulate various molecular pathways that are involved in inflammation, immune function, and nerve regeneration

Thus, OS in DM represents a paradigm of metabolic memory, where initial oxidative damage perpetuates dysfunction long after glycemic control is achieved, underscoring the need for early redox-targeted therapies