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Additionally, collagen-rich airway smooth muscle cells serve as a metastatic niche for bladder tumor cells expressing the collagen receptor CD167a, which activates the CD167a-HSP90-Stat3 axis, strengthens stemness, and promotes lung-specific colonization [195]

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In other cases, they can turn into a serious or even life-threatening problem

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Pein et al

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Guo MH, Zhao QL, Fan SJ, Wu ZQ, Lin LW, Chen HZ, et al

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