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Network pharmacology and experimental evidence: ERK/CREB/BDNF signaling pathway is involved in the antidepressive roles of Kaiyu Zhishen decoction

Further, elucidating more of the downstream effects of stress-induced modulation of m6A in the PFC and amygdala, in addition to the abnormal stress-coping behaviors observed in response to METTL3- and FTO-knockout, could provide valuable insights into their potential role in alcohol-related pathophysiology