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High NNMT activity has also been linked to: Poor mitochondrial function Increased oxidative stress Accelerated fat storage Inhibiting this enzyme helps reverse those metabolic imbalances

This was mirrored by reduced MuSC senescence and increased mitochondrial respiration and membrane potential in MuSCs, paralleled by improved fitness and exercise performance

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In animal studies, AOD-9604 treatment reduced body weight gain by over 50% compared to controls over a 19-day period, with increased lipolytic activity in adipose tissue