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This indicated that different bacterial GGTs can adopt different conformations

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The ligand exchange between Cl and H 2 O is known to be an equilibrium reaction 25,26 , and Cl -rich solutions can cause ligand re-exchange from [Pt(NH 3 ) 2 Cl(H 2 O)] + to Pt(NH 3 ) 2 Cl 2

For instance, exposure to H 2 O 2 led to a redistribution of ZO-1 from the TJs to the cytosol, resulting in a decrease in transepithelial electrical resistance (TEER) and an increase in BBB permeability ( 91 phox of NOX2 weakened the BBB damage induced by ischemic stroke in gp 91 phox -deficient mice to a great extent compared with wild-type mice ( 91 phox deficient mice is likely the result of less induction of MMP-9 and reduced loss of occludin, a critical TJs of the BBB (Van der Goes et al., 2001